Wonder No More (Part 2)
Back in September I blogged about the first test results I received following my new drug treatment regime of the cancer ‘wonder drug’ Dabrafenib. That scan showed a significant reduction in size (up to 25%) of the nodules in my lungs and no new disease. Since then I have had another full CT scan in January which has showed further decrease in the size of the lung nodules and has also showed my neck (the original source of the cancer) to be clear from disease.
Unfortunately, the scan also showed a spot had appeared in my brain which wasn’t present in the September scan. This has meant that I have been forced off the road for at least 12 months due to brain tumours causing increased risk of epileptic seizures.
Subsequent to finding this out, I have also been informed that due to the brain lesion being classified as ‘new disease’ that this shows that the cancer has built a resistance to the wonder drug, despite the evidence of positive results in my lungs. The upshot of this is that the hospital may not be allowed by the drug company that has been ‘sponsoring’ my use of Dabrafenib (GSK) to continue prescribing me the drug.
But before we get ahead of ourselves and think about throwing in the towel, the hospital has referred me for an MRI scan which will provide a more accurate picture of the brain than the CT scan can offer. They say that this will either confirm or refute the presence of cancer in my brain and, if present, will show how many spots there are and how big they are. The results of this will both determine my eligibility to remain on the drug and also give the Stereotactic Radiosurgery team in Dunedin hospital a better picture of my brain to assist them with the radiation treatment.
My oncologist has also said they are starting a phase 1 trial of a new kind of drug called an ERK inhibitor which targets a protein further down the chain from the B-RAF inhibitor drugs like Dabrafenib. This new type of inhibitor drug is even newer than the B-RAF inhibitors which have been trialled for the last few years. Auckland hospital is part of a group of hospitals performing these phase 1 trials of the ERK inhibitors so I would truly be a guinea pig for them to test the effectiveness of the drug and any potential side effects, some of which are still unknown.
So I await the results of my upcoming MRI scan and look forward with expectancy to see what miracles God will perform in my body through this. Let the adventure continue!
David
“God will keep in perfect peace all who trust in him, all whose thoughts are fixed on him” – Isaiah 26:3 (NLT)
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